Ketoconazole impurity 33 CAS CATO-C4X-147233
| CAS No. | CATO-C4X-147233 |
| Molecular Formula | C23H25BrCl2N2O4 |
| Molecular Weight | 544.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ketoconazole impurity 33.
Ketoconazole impurity 33 (CAS CATO-C4X-147233) is a certified pharmaceutical impurity reference standard with the molecular formula C23H25BrCl2N2O4 and a molecular weight of 544.27 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, Ketoconazole impurity 33 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 544.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ketoconazole impurity 33 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H25BrCl2N2O4 |
| Molecular Weight | 544.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Ketoconazole Standards
- Ketoconazole N-Oxide (and enantiomer) (CAS 254912-65-7)
- Ketoconazole N-Oxide (CAS 1392277-16-5)
- (+)-Ketoconazole (CAS 142128-59-4)
- Ketoconazole-d8 (CAS 1217706-96-1)
- Ketoconazole EP Impurity C (and enantiomer) (CAS 83374-59-8)
- Ketoconazole (CAS 65277-42-1)
- Ketoconazole Impurity 26 (CAS CATO-C4X-147226)
- Ketoconazole EP Impurity A (and enantiomer) (CAS 254912-63-5)
Recommended Standards
- 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxy-phosphoryl]oxymethyl]tetrahydrofuran-2-yl]-7-methyl-purin-7-ium-6-olate (CAS 26554-26-7)
- Methyltris(perfluorophenyl)silane (CAS 18920-98-4)
- 2,6-Bis((5-(3,4-dichlorophenyl)furan-2-yl)methylene)cyclohexanone (CAS 301312-59-4)
- Stampidine, >98% (HPLC) (CAS 217178-62-6)
- Lusutrombopag Impurity 3 (CAS CATO-C4X-20843)
- Fexofenadine Impurity 35 (CAS CATO-C4X-179435)
- Rosuvastatin Impurity 66 (CAS CATO-C4X-116966)
- Phenyl 3-hydroxy-3-methylazetidine-1-carboxylate (CAS 1485398-05-7)
- Ambrisentan-D10 (CAS 1046116-27-1)
- 1-Methylpyrido[2,3-b]pyrazine-2,3(1H,4H)-dione (CAS 67074-71-9)
- (2R)-2-Amino-3-(pyrrolidin-3-yl)propanoic acid 1313183-08-2 5804AA C7H14N2O2 (CAS 1313183-08-2)
- 1-(5-Hydroxy-2-methylpyridin-4-yl)ethan-1-one (CAS 1256809-33-2)
- 4-Methyl-5-(4-methylbenzenesulfinyl)-1,2,3-thiadiazole (CAS 282523-13-1)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com