Ketoconazole Impurity 26 CAS CATO-C4X-147226
| CAS No. | CATO-C4X-147226 |
| Molecular Formula | C25H24Cl2N4O5 |
| Molecular Weight | 531.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Ketoconazole Impurity 26 (CAS CATO-C4X-147226), a pharmacopoeial impurity reference standard (molecular formula C25H24Cl2N4O5, MW 531.39 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Ketoconazole Impurity 26 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 531.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H24Cl2N4O5 |
| Molecular Weight | 531.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Ketoconazole Standards
- Ketoconazole EP Impurity C (and enantiomer) (CAS 83374-59-8)
- Ketoconazole (CAS 65277-42-1)
- Ketoconazole EP Impurity A (and enantiomer) (CAS 254912-63-5)
- Ketoconazole-d8 (CAS 1217706-96-1)
- Ketoconazole impurity 33 (CAS CATO-C4X-147233)
- Ketoconazole impurity 27 (CAS CATO-C4X-147227)
- Ketoconazole N-Oxide (and enantiomer) (CAS 254912-65-7)
- Ketoconazole N-Oxide (CAS 1392277-16-5)
Recommended Standards
- Maribavir Impurity 10 (CAS CATO-C4X-300710)
- Tributylstannyl bis(trimethylsilyl) phosphate (CAS 74785-85-6)
- Gatifloxacin Impurity 32 (CAS CATO-C4X-125332)
- 4-(Ethoxycarbonyl)-3-methoxybenzoic acid (CAS 5462-88-4)
- Cyclosporin Impurity N33 (CAS 59865-23-5)
- Azacitidine Impurity 53 (CAS 27921-78-4)
- Pirfenidone Impurity 26 (CAS 4588-15-2)
- 4-(Benzyloxy)-2,3-dibromo-5-methoxybenzaldehyde (CAS 834907-51-6)
- 6-Chloro-2-methyl-4-morpholino-5-propoxypyridazin-3(2H)-one (CAS 61365-91-1)
- N-(6-Amino-4-cyclopropoxypyridin-2-yl)methanesulfonamide (CAS 1243382-48-0)
- 5-Phenylpyridazin-3(2H)-one (CAS 78920-21-5)
- (1-chlorohex-5-en-1-yl)benzene (CAS 61608-88-6)
- tert-Butyl 4-(5-amino-2-oxo-1,3-benzoxazol-3(2H)-yl)piperidine-1-carboxylate (CAS 1142202-16-1)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com