Naltrexone Impurity 28 CAS CATO-C4X-147528
| CAS No. | CATO-C4X-147528 |
| Molecular Formula | C21H26NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Naltrexone Impurity 28 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Naltrexone Impurity 28 (CAS CATO-C4X-147528), a pharmacopoeial impurity reference standard (molecular formula C21H26NO4Br, MW 436.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Naltrexone Impurity 28 (C21H26NO4Br) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Naltrexone Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H26NO4 Br |
| Molecular Weight | 436.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Naltrexone Standards
- Naltrexone EP Impurity A (CAS 1007856-83-8)
- Naltrexone Impurity 23 (CAS 102272-79-7)
- Naltrexone Impurity 15 (CAS 111129-14-7)
- Naltrexone impurity 30 (CAS 112242-13-4)
- Naltrexone Impurity 19 (CAS 112269-62-2)
- Naltrexone Impurity 13 (CAS 1201-90-7)
- Naltrexone Impurity 11 (CAS 123086-68-0)
- Naltrexone-D3 (CAS 1261080-26-5)
Recommended Standards
- Tacrolimus Impurity 17 (CAS CATO-C4X-130017)
- Sapropterin Impurity 4 (CAS CATO-C4X-27664)
- Brivudine Impurity 2 (CAS 765235-25-4)
- 2-[(2-Oxo-2-phenylethyl)sulfanyl]-5H,6H,7H,8H,9H,10H-cycloocta[b]pyridine-3-carbonitrile (CAS 166113-81-1)
- (-)-N-(1-R-Ethoxycarbonxyl-3-phenylpropyl)-D-alanine Benzyl Ester (CAS 93836-47-6)
- 3-Amino-4,6-dichloropicolinonitrile (CAS 1073182-86-1)
- 1-(2-Aminoethyl)-1H-pyrazole-4-sulfonamide (CAS 1539203-75-2)
- 2-Fluoro-6-(pyrrolidin-1-yl)-3-((trimethylsilyl)ethynyl)pyridine (CAS 1203499-05-1)
- 2-Benzylhydrazine-1-carbothioamide (CAS 7449-43-6)
- Semaglutide impurity 93 (CAS CATO-C4X-222693)
Why CATO?
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