Timolol EP Impurity B(Maleate) CAS CATO-C4X-149616
| CAS No. | CATO-C4X-149616 |
| Molecular Formula | C13H24N4O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Timolol EP Impurity B(Maleate) (CAS CATO-C4X-149616), a pharmacopoeial impurity reference standard (molecular formula C13H24N4O3SC4H4O4, MW 432.49 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Timolol EP Impurity B(Maleate) is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 432.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H24N4O3S C4H4O4 |
| Molecular Weight | 432.49 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Timolol Standards
- Timolol EP Impurity E (CAS 1026075-53-5)
- Timolol EP Impurity C (CAS 1391068-18-0)
- Timolol EP Impurity B（S-Isomer) (CAS 158636-96-5)
- Timolol EP Impurity H (CAS 158636-97-6)
- r-tImolol 2-butenedioate (CAS 1820576-27-9)
- Timolol Impurity 16 (CAS 214691-24-4)
- Timolol EP Impurity I (CAS 2469037-77-0)
- Timolol (CAS 26839-75-8)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com