Itraconazole Impurity 20 CAS CATO-C4X-149720
| CAS No. | CATO-C4X-149720 |
| Molecular Formula | - |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Itraconazole Impurity 20.
Itraconazole Impurity 20 (CAS CATO-C4X-149720) is a certified pharmaceutical impurity reference standard with the molecular formula C70H58D18Cl4N16O8 and a molecular weight of 1429.39 g/mol.
Itraconazole Impurity 20 (C70H58D18Cl4N16O8) contains deuterium isotope labeling, a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Itraconazole Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C70H58D18Cl4N16O8 |
| Molecular Weight | 1429.39 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 48.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 16 |
Related Itraconazole Standards
- Itraconazole Impurity 44 (CAS 103661-14-9)
- Itraconazole Impurity 41 (CAS 106461-41-0)
- Itraconazole Impurity 93 (CAS 110762-98-6)
- Itraconazole 2-Oxo Metabolite (CAS 112560-33-5)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- Itraconazole Impurity 73 (CAS 1199350-02-1)
- Itraconazole-d5(major) (CAS 1217510-38-7)
Recommended Standards
- Avibactam impurity 93 (CAS CATO-C4X-134893)
- Zolmitriptan Impurity 29 (CAS CATO-C4X-135129)
- Pheniramine Maleate （Dexchlorpheniramine EP Impurity A Maleate Salt） (CAS 132-20-7)
- Ethyl 1-butyl-5-oxopyrrolidine-3-carboxylate (CAS 192717-78-5)
- 3,3-DIchloro-5-(morpholin-4-ylsulfonyl)-1,3-dihydro-2h-indol-2-one (CAS 220428-21-7)
- 2-(((Tetrahydro-2H-pyran-2-yl)methyl)thio)-5-(2-(thiophen-2-yl)quinolin-4-yl)-1,3,4-oxadiazole (CAS 870757-54-3)
- 6-(Hydroxymethyl)-6-methylpiperidin-2-one (CAS 127274-93-5)
- 3-Amino-2,2-difluoropropan-1-ol hydrochloride (CAS 1314395-95-3)
- 2-Amino-N-(4-methylthiazol-2-yl)acetamide (CAS 359821-51-5)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com