Itraconazole Impurity 33 CAS CATO-C4X-149733
| CAS No. | CATO-C4X-149733 |
| Molecular Formula | C68H72Cl4N16O8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Itraconazole Impurity 33 (CAS CATO-C4X-149733) is a certified pharmaceutical impurity reference standard with the molecular formula C68H72Cl4N16O8 and a molecular weight of 1383.23 g/mol.
Based on its molecular formula C68H72Cl4N16O8, Itraconazole Impurity 33 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 1383.23 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C68H72Cl4N16O8 |
| Molecular Weight | 1383.23 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 39.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 16 |
Related Itraconazole Standards
- Itraconazole Impurity 44 (CAS 103661-14-9)
- Itraconazole Impurity 41 (CAS 106461-41-0)
- Itraconazole Impurity 93 (CAS 110762-98-6)
- Itraconazole 2-Oxo Metabolite (CAS 112560-33-5)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- Itraconazole Impurity 73 (CAS 1199350-02-1)
- Itraconazole-d5(major) (CAS 1217510-38-7)
Recommended Standards
- Istradefylline impurity 34 (CAS CATO-C4X-106134)
- Brivaracetam Impurity 1 (CAS 63095-60-3)
- Posaconazole Impurity 28 (CAS 1887197-42-3)
- 8-(1,3,4-Thiadiazol-2-yl)-8-azabicyclo[3.2.1]Octan-3-ol (CAS 1343918-50-2)
- 4-(2-Fluoropropan-2-yl)picolinic acid (CAS 1781062-53-0)
- 1-(3-Aminoazetidin-1-yl)-2-(4-chlorophenyl)ethan-1-one (CAS 1480155-22-3)
- 1-(2,4-Dichlorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000572-29-1)
- 5-Amino-2-(1H-imidazol-1-yl)-N-methylbenzamide (CAS 1322604-88-5)
- N-[4-(Methyloxy)phenyl]-2-nitroaniline (CAS 1416336-76-9)
- Semaglutide impurity 211 (CAS CATO-C4X-2226211)
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