Itraconazole Impurity 43 CAS CATO-C4X-149743
| CAS No. | CATO-C4X-149743 |
| Molecular Formula | C20H19Cl2N3O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Itraconazole Impurity 43 (CAS CATO-C4X-149743, C20H19Cl2N3O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H19Cl2N3O5S, Itraconazole Impurity 43 contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 484.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Itraconazole Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H19Cl2N3O5S |
| Molecular Weight | 484.35 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Itraconazole Standards
- Itraconazole Impurity 44 (CAS 103661-14-9)
- Itraconazole Impurity 41 (CAS 106461-41-0)
- Itraconazole Impurity 93 (CAS 110762-98-6)
- Itraconazole 2-Oxo Metabolite (CAS 112560-33-5)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- Itraconazole Impurity 73 (CAS 1199350-02-1)
- Itraconazole-d5(major) (CAS 1217510-38-7)
Recommended Standards
- Lansoprazole Impurity 43 (CAS CATO-C4X-111343)
- Levosimendan Impurity 7 (CAS 134678-47-0)
- Atenolol Impurity 12 (CAS 35198-42-6)
- Cefmetazole Impurity 64 (CAS CATO-C4X-150764)
- 3-(3-(4-Chlorophenyl)-3-oxoprop-1-en-1-yl)-4-methoxybenzene-1-sulfonyl chloride (CAS 728864-71-9)
- 6-(Hydroxymethyl)-6-methylpiperidin-2-one (CAS 127274-93-5)
- (1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid phenylmethyl ester (CAS 787640-37-3)
- tert-Butyl 3-hydroxy-3-(2-methoxy-5-methylphenyl)azetidine-1-carboxylate (CAS 1498368-17-4)
- 4-Amino-3-nitrobenzene-1-sulfonyl chloride (CAS 84202-56-2)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
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