Clomifene Citrate EP Impurity A CAS CATO-C4X-151216
| CAS No. | CATO-C4X-151216 |
| Molecular Formula | 2*C26H29NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Clomifene Citrate EP Impurity A (CAS CATO-C4X-151216, C26H29NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Clomifene Citrate EP Impurity A (C26H29NOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clomifene Citrate EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C26H29NO 2*HCl |
| Molecular Weight | 407.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Clomifene Standards
- Clomifene Impurity 9 (CAS 113454-71-0)
- Clomifene Citrate EP Impurity D (CAS 1391054-64-0)
- Clomifene Citrate - Impurity F (Citrate Salt) (CAS 14158-75-9)
- Clomifene 2-Chloro Citrate Salt (Mixture of Z and E Isomers) (CAS 1795130-18-5)
- Clomifene EP Impurity A (CAS 19957-52-9)
- Clomifene Impurity 8 (CAS 23464-17-7)
- Clomifene Impurity 17 (CAS 5530-99-4(free base))
- Clomifene EP Impurity C HCl (CAS 5635-70-1)
Recommended Standards
- Salicylic acid impurity 30 (CAS 2704-58-7)
- Ertapenem Impurity 12 (CAS CATO-C4X-163312)
- Atorvastatin Impurity 144 (CAS CATO-C4X-1132144)
- 2-Amino-6-bromo-4-chloropyridine (CAS 1206249-65-1)
- 2-O-Ethyl-2′-O-methyluridine (CAS 1352173-49-9)
- 3-((4-Ethoxyphenyl)amino)-1-(naphthalen-2-yl)propan-1-one (CAS 477320-02-8)
- tert-Butyl 2-bromo-6-cyano-1H-indole-1-carboxylate (CAS 1881288-64-7)
- n2,n2-Dimethyl-5h,6h,7h-cyclopenta[b]pyridine-2,4-diamine (CAS 297757-58-5)
- Methyl 3-(2-ethylphenyl)benzoate (CAS 1820619-10-0)
- Semaglutide impurity 109 (CAS CATO-C4X-2226109)
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