Atomoxetine Impurity 46 CAS CATO-C4X-155046
| CAS No. | CATO-C4X-155046 |
| Molecular Formula | C26H31NO2 |
| Molecular Weight | 389.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Atomoxetine Impurity 46 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Atomoxetine Impurity 46 (CAS CATO-C4X-155046) is a certified pharmaceutical impurity reference standard with the molecular formula C26H31NO2 and a molecular weight of 389.53 g/mol.
The molecular framework of Atomoxetine Impurity 46 (C26H31NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H31NO2 |
| Molecular Weight | 389.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Atomoxetine Standards
- Atomoxetine Impurity 54 (CAS CATO-C4X-155054)
- Atomoxetine Impurity 3 (CAS 93982-97-9)
- Atomoxetine Impurity 18 (CAS CATO-C4X-155018)
- Atomoxetine Impurity 21 (CAS CATO-C4X-155021)
- Atomoxetine Impurity 33 (CAS CATO-C4X-155033)
- Atomoxetine Impurity 23 (CAS CATO-C4X-155023)
- Atomoxetine Impurity 22 (CAS 881995-45-5)
- Atomoxetine Impurity 26 (CAS CATO-C4X-155026)
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