Cetirizine Impurity 27 CAS CATO-C4X-158227
| CAS No. | CATO-C4X-158227 |
| Molecular Formula | C19H23ClN2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Cetirizine Impurity 27 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Cetirizine Impurity 27 (CAS CATO-C4X-158227), a pharmacopoeial impurity reference standard (molecular formula C19H23ClN2OHCl, MW 367.31 g/mol) used for the identification and quantification of trace impurities in APIs.
Cetirizine Impurity 27 (C19H23ClN2OHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H23ClN2O 2*HCl |
| Molecular Weight | 367.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cetirizine Standards
- Cetirizine EP Impurity B (CAS 1000690-91-4)
- Cetirizine Impurity 10 (CAS 1016-78-0)
- rac Cetirizine N-Oxide (Mixture of Diastereomers) (CAS 1076199-80-8)
- Cetirizine USP Related Compound B (CAS 108983-83-1)
- Cetirizine EP Impurity G (CAS 109806-71-5)
- (R)-Cetirizine-d4 Dihydrochloride (CAS 1133210-23-7)
- Cetirizine Impurity N19 (CAS 113740-61-7)
- rac Cetirizine-d8 N-Oxide (CAS 1216444-13-1)
Recommended Standards
- Terbinafine Impurity 47 (CAS CATO-C4X-133847)
- Phenylbutyrate EP Impurity A (CAS 2051-95-8)
- Finerenone Impurity 39 (CAS CATO-C4X-288039)
- 5-Amino-4-(propan-2-yl)-4h-1,2,4-triazole-3-thiol (CAS 88312-58-7)
- 1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-toluoyl-D-ribofuranose (CAS 120143-22-8)
- 2,4,5-Trifluorothioanisole (CAS 54378-74-4)
- Ethyl 4-chlorothiazole-5-carboxylate (CAS 444909-55-1)
- Methyl 4-chloro-2-methoxypyrimidine-5-carboxylate (CAS 1894033-88-5)
- 4,4'-(Ethyne-1,2-diyl)diphthalic Anhydride (purified by sublimation) (CAS 129808-00-0)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com