Estradiol Impurity 58 CAS CATO-C4X-163658
| CAS No. | CATO-C4X-163658 |
| Molecular Formula | C19H24O3 |
| Molecular Weight | 300.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Estradiol Impurity 58 (CAS CATO-C4X-163658), a pharmacopoeial impurity reference standard (molecular formula C19H24O3, MW 300.39 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Estradiol Impurity 58 (C19H24O3) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H24O3 |
| Molecular Weight | 300.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Estradiol Standards
- Estradiol Impurity N3 (CAS 4954-14-7)
- Estradiol Impurity N2 (CAS 92817-10-2)
- Estradiol Impurity 10 (CAS 1229-24-9)
- Estradiol Impurity 11 (CAS 3583-03-7)
- Estradiol Valerate Impurity 12 (CAS 10582-53-3)
- Estradiol 3-Methyl Ether (CAS 1035-77-4)
- Estradiol Hemihydrate EP Impurity C (CAS 6171-48-8)
- Estradiol Impurity 28 (CAS 3597-38-4)
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Why CATO?
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