Ketorolac impurity 67 CAS CATO-C4X-166967
| CAS No. | CATO-C4X-166967 |
| Molecular Formula | C17H18ClNO3 |
| Molecular Weight | 319.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ketorolac impurity 67 (CAS CATO-C4X-166967) is a certified pharmaceutical impurity reference standard with the molecular formula C17H18ClNO3 and a molecular weight of 319.78 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Ketorolac impurity 67 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 319.78 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ketorolac impurity 67 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H18ClNO3 |
| Molecular Weight | 319.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ketorolac Standards
- Ketorolac Impurity 76 (CAS CATO-C4X-166976)
- Ketorolac impurity 70 (CAS CATO-C4X-166970)
- Ketorolac 2-Benzoylpyrrole Iodo Impurity (CAS 141031-77-8)
- Ketorolac Impurity 42 (CAS 144710-35-0)
- Ketorolac Impurity 78 (CAS CATO-C4X-166978)
- Ketorolac Impurity 79 (CAS CATO-C4X-166979)
- Ketorolac Impurity 29 (CAS CATO-C4X-166929)
- Ketorolac Impurity 40 (CAS CATO-C4X-166940)
Recommended Standards
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- Pranoprofen Impurity 23 (CAS CATO-C4X-181123)
- N-[4-(benzyloxy)-3-methoxybenzyl]-2-chloroacetamide (CAS 879319-21-8)
- Fesoterodine Impurity N14 (CAS 895137-81-2)
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- Fluralaner impurity 41 (CAS CATO-C4X-218041)
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