Riociguat Impurity 37 CAS CATO-C4X-174937
| CAS No. | CATO-C4X-174937 |
| Molecular Formula | C21H21FN8O2 |
| Molecular Weight | 436.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 436.44 g/mol gives Riociguat Impurity 37 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Riociguat Impurity 37 (CAS CATO-C4X-174937), a pharmacopoeial impurity reference standard (molecular formula C21H21FN8O2, MW 436.44 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Riociguat Impurity 37 (C21H21FN8O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Riociguat Impurity 37 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H21FN8O2 |
| Molecular Weight | 436.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Riociguat Standards
- Riociguat EP Impurity C (CAS CATO-C4X-174914)
- Riociguat Impurity 19 (CAS CATO-C4X-174919)
- Riociguat Impurity 40 (CAS CATO-C4X-174940)
- Riociguat EP Impurity C (CAS 2920299-23-4)
- Riociguat Impurity 32 (CAS CATO-C4X-174932)
- Riociguat Impurity 33 (CAS CATO-C4X-174933)
- Riociguat Impurity 4 (CAS CATO-C4X-17494)
- Riociguat Impurity N2 （E-isomer） (CAS 370879-49-5)
Recommended Standards
- Betamethasone impurity 99 (CAS CATO-C4X-143799)
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- 4,4'-(Benzo[c][1,2,5]thiadiazole-4,7-diyl)bis(3-methoxybenzoic acid) (CAS 2328097-10-3)
- 2-(4-(3-(Thiophen-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-N-(2-(trifluoromethyl)phenyl)acetamide (CAS 1251625-52-1)
- Mesna EP Impurity E (CAS 1391054-56-0)
- Gefitinib Impurity 76 (CAS CATO-C4X-111776)
- Hydrochlorothiazide Impurity 15 (CAS 23141-75-5)
- 4-Butoxy-3-fluorobenzoic acid (CAS 326-76-1)
- N,N-Diethyl-2-(2-(methylsulfonyl)-1H-benzo[d]imidazol-1-yl)acetamide (CAS 886922-49-2)
- 8-Oxa-2-azaspiro[4.5]decane oxalate(2:1) (CAS 1651840-84-4)
- Enalaprilat tert-Butyl Ester (CAS 674796-29-3)
- 1-(3,4-dimethylphenyl)-1H-imidazole-2-thiol (CAS 851207-77-7)
- 2,3,3-Trichloro-N-(6-(4-fluorophenoxy)pyridin-3-yl)acrylamide (CAS 219929-62-1)
- [Nva12]-Tirzepatide (CAS CATO-C4X-324042)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com