Riociguat Impurity 36 CAS CATO-C4X-174936
| CAS No. | CATO-C4X-174936 |
| Molecular Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Riociguat Impurity 36 (CAS CATO-C4X-174936, C19H17FN8O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H17FN8O2, Riociguat Impurity 36 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 408.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Riociguat Impurity 36 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Riociguat Standards
- Riociguat EP Impurity A (CAS 625115-52-8)
- Riociguat Impurity 41 (CAS CATO-C4X-174941)
- Riociguat EP Impurity B (CAS 3052969-92-0)
- Riociguat Impurity 18 (CAS 1361569-23-4)
- Riociguat Impurity 21 (CAS CATO-C4X-174921)
- Riociguat Impurity 11 (CAS CATO-C4X-174911)
- Riociguat Impurity 12 (CAS CATO-C4X-174912)
- Riociguat (CAS 625115-55-1)
Recommended Standards
- Tarafenacin (CAS 385367-47-5)
- 9-methyl-5-(((trifluoromethyl)sulfonyl)oxy)-2,3-dihydrobenzo[b]oxepin-8-yl pivalate (CAS 2226905-38-8)
- Vericiguat Impurity 100 (CAS 1011527-86-8)
- 7-Methyl-5-(((trifluoromethyl)sulfonyl)oxy)-2,3-dihydrobenzo[b]oxepin-8-yl pivalate (CAS 2226905-20-8)
- Pyridoxine Impurity 60 (CAS 22464-27-3)
- Rac-Melphalan EP Impurity A DiHCl (Dihydroxy Melphalan DiHCl) (CAS CATO-C4X-198814)
- Baricitinib Impurity 87 (CAS CATO-C4X-226087)
- 2-(4-(4-Methoxyphenyl)-tetrahydro-2H-pyran-4-yl)acetic acid (CAS 1225481-64-0)
- 5-Methoxy-4-[(4-methoxyphenyl)sulfanyl]-2-phenylpyrimidine (CAS 477872-59-6)
- [2,2-Difluoro-1-(hydroxymethyl)cyclopropyl]methanol (CAS 228580-15-2)
- 3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)morpholine (CAS 1461707-79-8)
- 3-(5-(((Benzyloxy)carbonyl)amino)pyridin-3-yl)propanoic acid (CAS 1881328-42-2)
- 4-(4-Chloro-3-pyridyl)-4-oxobutyronitrile (CAS 890100-84-2)
- Peptide Impurity 15 (CAS 1227750-69-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com