Tenofovir alafenamide impurity 72 CAS CATO-C4X-179772
| CAS No. | CATO-C4X-179772 |
| Molecular Formula | C19H25N6O5P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C19H25N6O5PC4H4O4, Tenofovir alafenamide impurity 72 contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 564.49 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Tenofovir alafenamide impurity 72 (CAS CATO-C4X-179772, C19H25N6O5PC4H4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H25N6O5P C4H4O4 |
| Molecular Weight | 564.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 79 (CAS 102-10-3)
- rac Tenofovir-d6 (CAS 1020719-94-1)
- Tenofovir disoproxil Impurity 142 (CAS 102537-97-3)
- Tenofovir Disoproxil Dimer (CAS 1093279-76-5)
- Tenofovir disoproxil Impurity 6 (CAS 1093279-77-6)
- Tenofovir disoproxil Impurity 28 (CAS 1115-59-9)
- Tenofovir Impurity 59 (CAS 116384-56-6)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
Recommended Standards
- Clopidogrel Impurity 116 (CAS 1801260-45-6)
- Amlexanox Impurity 7 (CAS CATO-C4X-21767)
- Ceritinib Impurity 69 (CAS CATO-C4X-104869)
- Metoclopramide impurity 70 (CAS 102313-35-9)
- 1-(3-Chloro-5-trifluoromethyl-pyridin-2-ylmethyl)-piperidine-4-carbothioic acid S-(4-chloro-phenyl) ester (CAS 1311279-18-1)
- 2-Oxo-1-phenyl-1,2-dihydropyridine-3-carboxylicacid (CAS 868171-81-7)
- (1S,2R,1'S)-Cypermethrin (CAS 83860-31-5)
- Ethyl 2-((1,3-dioxoisoindolin-2-yl)oxy)propanoate (CAS 40674-15-5)
- 2,6-Dihydroxy-5-methoxy-4-methylnicotinonitrile (CAS 1704065-88-2)
- Neuropeptide Y (1-24) amide (human, rat) (CAS 131448-51-6)
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