Nintedanib Impurity 115 CAS CATO-C4X-1814115
| CAS No. | CATO-C4X-1814115 |
| Molecular Formula | C32H36N5O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nintedanib Impurity 115 (CAS CATO-C4X-1814115) is a certified pharmaceutical impurity reference standard with the molecular formula C32H36N5O4I and a molecular weight of 681.57 g/mol.
The molecular framework of Nintedanib Impurity 115 (C32H36N5O4I) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 115 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H36N5O4 I |
| Molecular Weight | 681.57 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 5 |
Related Nintedanib Standards
- Nintedanib Impurity 158 (CAS 1023942-14-4)
- Nintedanib Impurity 9 (CAS 1038972-16-5)
- Nintedanib Impurity 156 (CAS 1040320-04-4)
- Nintedanib Impurity 19 (CAS 1125-88-8)
- Nintedanib Impurity 6 (CAS 1139453-98-7)
- Nintedanib Impurity N24 (CAS 1139455-52-9)
- Nintedanib Impurity N10 (CAS 1139457-10-5)
- Nintedanib Impurity N8 (CAS 1139458-48-2)
Recommended Standards
- Rotigotine Impurity 33 (CAS CATO-C4X-192733)
- Resmetirom impurity 78 (CAS CATO-C4X-291278)
- Granisetron EP Impurity H (CAS 4498-67-3)
- (5-Methyl-6-(piperazin-1-yl)pyridin-3-yl)methanol (CAS 1355202-96-8)
- 4-((Benzo[d]oxazol-2-ylamino)methyl)tetrahydro-2h-pyran-4-ol (CAS 1333654-70-8)
- 1274947-94-2 1-((4-Bromophenyl)sulfonyl)-1-nitro-2-((4-(trifluoromethyl)(2-pyridyl))amino)ethene MFCD00245052 (CAS 1274947-94-2)
- 2-Bromo-3-nitrobenzonitrile (CAS 90407-28-6)
- 3-[(4-oxo-1,4-dihydro-2-pyrimidinyl)amino]benzoic acid 944795-45-3 (CAS 944795-45-3)
- 8-chloro-1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline (CAS 1541583-91-8)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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