Granisetron EP Impurity H CAS 4498-67-3
| CAS No. | 4498-67-3 |
| Molecular Formula | C8H6N2O2 |
| Molecular Weight | 162.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Granisetron EP Impurity H (CAS 4498-67-3) is a certified pharmaceutical impurity reference standard with the molecular formula C8H6N2O2 and a molecular weight of 162.15 g/mol.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Granisetron EP Impurity H is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 162.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Granisetron EP Impurity H under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6N2O2 |
| Molecular Weight | 162.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Granisetron Standards
- Granisetron EP Impurity E (CAS 76272-56-5)
- Granisetron EP Impurity D (CAS 50890-83-0)
- Granisetron EP Impurity G (CAS 34252-44-3)
- Granisetron Impurity 12 (CAS 106649-02-9)
- Granisetron Impurity 10 (CAS 123704-99-4)
- Granisetron Impurity 11(Mixture of Z and E Isomers) (CAS 123704-98-3)
- Granisetron Impurity 27 (CAS 10604-20-3)
- Granisetron Impurity 24 (CAS CATO-C4X-197024)
Recommended Standards
- Lenalidomide Impurity 71 (CAS CATO-C4X-190371)
- Niraparib Impurity 58 (CAS 2069617-23-6)
- Polaprezinc impurity 32 (CAS CATO-C4X-182132)
- 2-(2-Nitrophenyl)acetonitrile (CAS 610-66-2)
- Pemetrexed Impurity 52 (CAS CATO-C4X-172652)
- Nelarabine Impurity 4 (CAS 15830-52-1)
- Mometasone Furoate EP Impurity Q (CAS 83881-08-7)
- 7-Dimethylaminocoumarin-4-acetic acid, 96% (CAS 80883-54-1)
- N-Benzyl-4-fluorobenzo[d]thiazol-2-amine (CAS 862975-05-1)
- 3-bromo-4-methoxypyridine (CAS 82257-09-8)
- 2-[2-(pyrimidin-2-yl)-1,3-thiazol-4-yl]acetic acid (CAS 1154009-60-5)
- N-(5-Chloro-2-methoxyphenyl)-2-(10-(morpholine-4-carbonyl)-3,4-dihydrobenzo[b][1,6]naphthyridin-2(1H)-yl)acetamide (CAS 1228168-21-5)
- HO-Ste-γGlu-AEEA-AEEA-AEEA-OH (CAS CATO-C4X-2226285)
- Tirzepatide Impurity 9 (CAS CATO-C4X-32409)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com