N-nitroso hydroxychloroquine EP Impurity D CAS CATO-C4X-183566
| CAS No. | CATO-C4X-183566 |
| Molecular Formula | C16H21ClN4O |
| Molecular Weight | 320.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-nitroso hydroxychloroquine EP Impurity D (C16H21ClN4O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies N-nitroso hydroxychloroquine EP Impurity D (CAS CATO-C4X-183566), a pharmacopoeial impurity reference standard (molecular formula C16H21ClN4O, MW 320.82 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H21ClN4O |
| Molecular Weight | 320.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- N-Nitroso-(S,S)-ethylenediamine-N,N'-disuccinic acid (CAS CATO-C3D-26116)
- N-Nitroso Levobunolol (CAS CATO-C4X-29661)
- N-nitroso zolmitriptan D6 (CAS CATO-C4X-135139)
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Recommended Standards
- 2-(4-(4-(4-Chloro-1H-pyrazol-1-yl)butyl)piperazin-1-yl)pyrimidine (CAS 132449-46-8)
- 2,3,4-Tribromothiophene (CAS 3141-25-1)
- tert-Butyl ((2S,4R)-1-azido-7-chloro-4-(hydroxymethyl)heptan-2-yl)carbamate (CAS 1013937-97-7)
- 2,3,5-Tribromothiophene (CAS 3141-24-0)
- Orforglipron Impurity 145 (CAS CATO-C4X-3234145)
- Gadobutrol Impurity 144 (CAS CATO-C4X-2120144)
- Abemaciclib Impurity 59 (CAS CATO-C4X-293759)
- (3-(Benzyloxy)-4-bromophenyl)methanol (CAS 540779-36-0)
- {4-[(2-methoxyethoxy)methyl]phenyl}methanamine (CAS 1016496-34-6)
- Levonorgestrel EP Impurity W (CAS 155683-59-3)
- 1-(4-Methoxyphenyl)-1H-1,2,4-triazole-3-carbaldehyde (CAS 917910-97-5)
- Diphenylgallium chloride (CAS 1079-63-6)
- N-((1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)-3-morpholinopropan-1-amine dihydrochloride (CAS 1856073-24-9)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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