Clemastine Impurity 14 CAS CATO-C4X-183714
| CAS No. | CATO-C4X-183714 |
| Molecular Formula | C22H28ClNO |
| Molecular Weight | 357.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clemastine Impurity 14.
CATO supplies Clemastine Impurity 14 (CAS CATO-C4X-183714), a pharmacopoeial impurity reference standard (molecular formula C22H28ClNO, MW 357.92 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Clemastine Impurity 14 (C22H28ClNO) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Clemastine Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H28ClNO |
| Molecular Weight | 357.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Clemastine Standards
- Clemastine Impurity 24 (CAS CATO-C4X-183724)
- Clemastine EP Impurity A(Mixture of Diastereomers) (CAS 108825-05-4)
- Clemastine Impurity 33 (CAS CATO-C4X-183733)
- rac-Clemastine Fumarate EP Impurity B (CAS 61771-18-4)
- Clemastine Impurity 15 (CAS CATO-C4X-183715)
- Clemastine Impurity 16 (CAS CATO-C4X-183716)
- Clemastine EP Impurity B (CAS 1352549-49-5)
- Clemastine Impurity 21 (CAS CATO-C4X-183721)
Recommended Standards
- 4,5,6,7-Tetrafluoro-2-(perfluorophenyl)benzo[d][1,3,2]dioxaborole (CAS 365458-36-2)
- 1-Bromo-2-iodo-3-methoxy-5-nitrobenzene (CAS 1160574-50-4)
- 3,4-Diiodobenzaldehyde (CAS 477534-94-4)
- 1-Bromo-2-iodo-5-methoxy-3-nitrobenzene (CAS 1263376-99-3)
- Iohexol impurity 43 (CAS CATO-C4X-166443)
- Polaprezinc impurity 28 (CAS CATO-C4X-182128)
- Epinephrine Impurity 69 (CAS CATO-C4X-184969)
- 2'H-1,2'-Biimidazole (CAS 95923-46-9)
- tert-Butyl 4-methyl-3,4-dihydropyridine-1(2H)-carboxylate (CAS 1257080-97-9)
- Oxetan-2-ylmethanol (CAS 61266-70-4)
- 2,4-Dichloro-7-methoxy-3-phenylquinoline (CAS 108832-16-2)
- 2-((3-(3-Bromophenyl)-1H-1,2,4-triazol-5-yl)thio)-N-(5-chloro-2-methoxyphenyl)acetamide (CAS 332127-56-7)
- (4R)-4-Amino-1-[(2-chlorophenyl)methyl]pyrrolidin-2-one (CAS 1638744-39-4)
- Allo-D-Ile12-Tirzepatide (CAS CATO-CPTD788963)
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