Paclitaxel Impurity 59 CAS CATO-C4X-184259
| CAS No. | CATO-C4X-184259 |
| Molecular Formula | C46H55NO14 |
| Molecular Weight | 845.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Paclitaxel Impurity 59.
CATO supplies Paclitaxel Impurity 59 (CAS CATO-C4X-184259), a pharmacopoeial impurity reference standard (molecular formula C46H55NO14, MW 845.93 g/mol) used for the identification and quantification of trace impurities in APIs.
Paclitaxel Impurity 59 (C46H55NO14) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C46H55NO14 |
| Molecular Weight | 845.93 g/mol |
| Purity | ≥90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Paclitaxel Standards
- Paclitaxel EP Impurity Q (CAS 502626-06-4)
- Paclitaxel EP Impurity C (CAS 153415-45-3)
- Paclitaxel Photodegradant (CAS 146139-03-9)
- Paclitaxel EP Impurity E (CAS 105454-04-4)
- Paclitaxel (CAS 33069-62-4)
- Paclitaxel EP Impurity R (CAS 158948-96-0)
- Paclitaxel Impurity R (CAS 159001-25-9)
- Paclitaxel Impurity 38 (CAS 173101-55-8)
Recommended Standards
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- Gefitinib Impurity 57 (CAS 861453-11-4)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com