Arotinolol Impurity 60 CAS CATO-C4X-185460
| CAS No. | CATO-C4X-185460 |
| Molecular Formula | C11H9ClN2OS3 |
| Molecular Weight | 316.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Arotinolol Impurity 60 (CAS CATO-C4X-185460, C11H9ClN2OS3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Arotinolol Impurity 60 (C11H9ClN2OS3) contains a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9ClN2OS3 |
| Molecular Weight | 316.85 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 3 |
Related Arotinolol Standards
- Arotinolol Impurity 53 (CAS CATO-C4X-185453)
- Arotinolol Impurity 20 (CAS CATO-C4X-185420)
- Arotinolol Impurity 75 (CAS CATO-C4X-185475)
- Arotinolol Impurity 69 (CAS CATO-C4X-185469)
- Arotinolol Impurity 73 (CAS CATO-C4X-185473)
- Arotinolol Impurity 78 (CAS CATO-C4X-185478)
- Arotinolol impurity 24 (CAS CATO-C4X-185424)
- Arotinolol Impurity 21 (CAS CATO-C4X-185421)
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