Etomidate impurity 60 CAS CATO-C4X-188460
| CAS No. | CATO-C4X-188460 |
| Molecular Formula | C12H13NO4 |
| Molecular Weight | 235.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Etomidate impurity 60 (C12H13NO4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Etomidate impurity 60 (CAS CATO-C4X-188460, C12H13NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13NO4 |
| Molecular Weight | 235.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Etomidate Standards
- Etomidate Impurity 27 (CAS CATO-C4X-188427)
- Etomidate impurity 01 (CAS 66512-38-7)
- Etomidate Impurity 20 (CAS CATO-C4X-188420)
- Etomidate Impurity 7 (CAS 66514-85-0)
- Etomidate Impurity 44 (CAS 39096-80-5)
- Etomidate Impurity 76 (CAS CATO-C4X-188476)
- （R)-Etomidate EP Impurity B (CAS 61045-91-8)
- S-(-)-Etomidate (CAS 56649-47-9)
Recommended Standards
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- Rivaroxaban Impurity 208 (CAS CATO-C4X-1090208)
- Moxonidine impurity 4 (CAS CATO-C4X-27814)
- Gefitinib Impurity 10 (CAS 1603814-04-5)
- Erlotinib Impurity N54 (CAS 2055841-67-1)
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