Esmolol Impurity 21 CAS CATO-C4X-189121
| CAS No. | CATO-C4X-189121 |
| Molecular Formula | C12H16O5 |
| Molecular Weight | 240.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Esmolol Impurity 21 (CAS CATO-C4X-189121, C12H16O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Esmolol Impurity 21 (C12H16O5) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H16O5 |
| Molecular Weight | 240.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Esmolol Standards
- Esmolol Impurity 78 (CAS CATO-C4X-189178)
- Esmolol Impurity N2 (CAS 112805-58-0)
- Esmolol Impurity 54 (CAS CATO-C4X-189154)
- Esmolol Impurity 67 (CAS CATO-C4X-189167)
- Esmolol Impurity 8 (CAS 81147-94-6)
- Esmolol Impurity 48 (CAS CATO-C4X-189148)
- Esmolol Impurity 87 (CAS CATO-C4X-189187)
- Esmolol Impurity 96 (CAS CATO-C4X-189196)
Recommended Standards
- Paliperidone Impurity 81 (CAS 691007-07-5)
- Roxadustat Impurity 166 (CAS CATO-C4X-2213166)
- Paliperidone Impurity 78 (CAS 691007-05-3)
- Phloroglucinol Impurity 63 (CAS CATO-C4X-221763)
- Opicapone impurity 30 (CAS CATO-C4X-240430)
- Finerenone Impurity 279 (CAS CATO-C4X-2880279)
- (2R,3S)-Isavuconazole Impurity 25 (CAS 1797905-83-9)
- 1-(2-Fluorophenyl)ethanol (CAS 445-26-1)
- 4,4′-[[4-(4-Pyridinyl)phenyl]imino]bis[benzoic acid] (CAS 1620819-71-7)
- 2-[4-(sec-Butyl)phenoxy]-5-fluoroaniline (CAS 946684-05-5)
- 3-phenyl-1-indanone (CAS 16618-72-7)
- 2-Methyl-5-((phenylthio)methyl)-1,2-dihydro-3H-pyrazol-3-one (CAS 318234-24-1)
- tert-Butyl 4-(cyanomethylene)piperidine-1-carboxylate (CAS 197569-11-2)
- D-Ala18-Tirzepatide (CAS CATO-CPTD788916)
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