Esketamine Impurity 8 CAS CATO-C4X-19048
| CAS No. | CATO-C4X-19048 |
| Molecular Formula | C13H15BrClNO |
| Molecular Weight | 316.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Esketamine Impurity 8 (CAS CATO-C4X-19048, C13H15BrClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H15BrClNO, Esketamine Impurity 8 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 316.62 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H15BrClNO |
| Molecular Weight | 316.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Esketamine Standards
- Esketamine Impurity 9 (CAS CATO-C4X-19049)
- Esketamine Impurity 7 (CAS CATO-C4X-19047)
- Esketamine Impurity 5 (CAS 86144-35-6)
- Esketamine (CAS 33643-46-8)
- Esketamine EP Impurity D (CAS 33643-49-1)
- Esketamine Hydrochloride (CAS 33643-47-9)
- 【禁售不询】Esketamine Impurity N1 (CAS 6740-88-1)
- Esketamine EP Impurity C (CAS 90717-17-2)
Recommended Standards
- Cyclohexyl 5-bromo-2-chlorobenzamide (CAS 701260-15-3)
- 2-chloro-1-(oxan-2-yl)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole (CAS 1029684-36-3)
- 4-Bromo-2-chloro-N-cyclohexylbenzamide (CAS 1456371-43-9)
- Diflubenzuron-13C6 (CAS 1581694-97-4)
- Voriconazole Impurity 15 (CAS 137234-76-5)
- Dotinurad Impurity 51 (CAS CATO-C4X-249451)
- Policresulen Impurity 17 (CAS 4198-72-5)
- 2-(Quinolin-8-yl)isoindoline-1,3-dione (CAS 19348-61-9)
- 2-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)acetic acid (CAS 104189-85-7)
- 3,4-Dimethoxy-1,2,5-thiadiazole (CAS 55904-37-5)
- (Oxan-4-yl)thiourea (CAS 1153229-49-2)
- 4-(Bromomethyl)-2,3-dimethylpyridine (CAS 2090991-73-2)
- 2-bromo-1-(2,5-dimethyloxazol-4-yl)ethanone (CAS 113732-62-0)
- Mast Cell Degranulating (MCD) Peptide (CAS 32908-73-9)
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