Esketamine Impurity 5 CAS 86144-35-6
| CAS No. | 86144-35-6 |
| Molecular Formula | C13H15ClN2O2 |
| Molecular Weight | 266.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Esketamine Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Esketamine Impurity 5 (CAS 86144-35-6), a pharmacopoeial impurity reference standard (molecular formula C13H15ClN2O2, MW 266.72 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Esketamine Impurity 5 (C13H15ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 266.72 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H15ClN2O2 |
| Molecular Weight | 266.72 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Esketamine Standards
- Esketamine (CAS 33643-46-8)
- Esketamine EP Impurity D (CAS 33643-49-1)
- Esketamine Hydrochloride (CAS 33643-47-9)
- 【禁售不询】Esketamine Impurity N1 (CAS 6740-88-1)
- Esketamine EP Impurity C (CAS 90717-17-2)
- Esketamine Impurity 8 (CAS CATO-C4X-19048)
- Esketamine Impurity 9 (CAS CATO-C4X-19049)
- Esketamine Impurity 7 (CAS CATO-C4X-19047)
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Why CATO?
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