Pimavanserin Impurity 14 CAS CATO-C4X-193814
| CAS No. | CATO-C4X-193814 |
| Molecular Formula | C19H22F2N2 |
| Molecular Weight | 316.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pimavanserin Impurity 14.
As a process- or degradation-related impurity, Pimavanserin Impurity 14 (CAS CATO-C4X-193814, C19H22F2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Pimavanserin Impurity 14 (C19H22F2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22F2N2 |
| Molecular Weight | 316.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Pimavanserin Standards
- Pimavanserin Impurity 19 (CAS CATO-C4X-193819)
- Pimavanserin Impurity 36 (CAS 1983947-08-5)
- Pimavanserin Impurity 27 (CAS CATO-C4X-193827)
- Pimavanserin Impurity 50 (CAS CATO-C4X-193850)
- Pimavanserin Impurity 67 (CAS CATO-C4X-193867)
- Pimavanserin Impurity 40 (CAS CATO-C4X-193840)
- Pimavanserin Impurity 12 (CAS CATO-C4X-193812)
- Pimavanserin Impurity 2 (CAS 103907-97-7)
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