Brinzolamide Impurity 27 CAS CATO-C4X-194027

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-194027
Molecular FormulaC6H4Br2ClNO3S2
Molecular Weight397.49 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Brinzolamide Impurity 27 CAS CATO-C4X-194027 chemical structure

Description

The occurrence of Brinzolamide Impurity 27 is closely related to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Brinzolamide Impurity 27 (CAS CATO-C4X-194027) is a certified pharmaceutical impurity reference standard with the molecular formula C6H4Br2ClNO3S2 and a molecular weight of 397.49 g/mol.

Based on its molecular formula C6H4Br2ClNO3S2, Brinzolamide Impurity 27 contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 397.49 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC6H4Br2ClNO3S2
Molecular Weight397.49 g/mol
Purity≥95%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO, water
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl/Br-containing
Nitrogen Atoms1
Sulfur Atoms2

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