(R,S,S,S)-Nebivolol D4 CAS CATO-C4X-196887
| CAS No. | CATO-C4X-196887 |
| Molecular Formula | - |
| Molecular Weight | 409.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 409.46 g/mol gives (R,S,S,S)-Nebivolol D4 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies (R,S,S,S)-Nebivolol D4 (CAS CATO-C4X-196887), a certified reference material (molecular formula C22H21D4F2NO4, MW 409.46 g/mol) for analytical method development and quality control.
The molecular framework of (R,S,S,S)-Nebivolol D4 (C22H21D4F2NO4) is characterized by deuterium isotope labeling, a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21D4F2NO4 |
| Molecular Weight | 409.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Glimepiride EP Impurity F (CAS CATO-C4X-11026)
- (S,R,R,R)-Nebivolol D4 (CAS 118457-15-1(Unlabelled))
- Glimepiride EP Impurity C (CAS 119018-30-3)
- rac Nebivolol-d4 (CAS 1219407-55-2)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com