Nebivolol Impurity 89 CAS CATO-C4X-196889
| CAS No. | CATO-C4X-196889 |
| Molecular Formula | C28H35F2NO9 |
| Molecular Weight | 567.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Nebivolol Impurity 89 (CAS CATO-C4X-196889), a pharmacopoeial impurity reference standard (molecular formula C28H35F2NO9, MW 567.58 g/mol) used for the identification and quantification of trace impurities in APIs.
Nebivolol Impurity 89 (C28H35F2NO9) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H35F2NO9 |
| Molecular Weight | 567.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 100 (CAS CATO-C4X-1968100)
- Nebivolol Impurity 91 (CAS CATO-C4X-196891)
- Nebivolol Impurity 97 (CAS CATO-C4X-196897)
- Nebivolol Impurity 99 (CAS CATO-C4X-196899)
- Nebivolol Impurity N1 (CAS 929706-85-4)
- Nebivolol Impurity 35 (CAS 1199945-26-0)
- Nebivolol Impurity 101 (CAS CATO-C4X-1968101)
- Nebivolol Impurity 96 (CAS CATO-C4X-196896)
Recommended Standards
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- Ubrogepant Impurity 8 (CAS CATO-C4X-34028)
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- Ceritinib Impurity 41 (CAS CATO-C4X-104841)
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- 2-Amino-6-(hydroxymethyl)-4-(2-isopropoxyphenyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile (CAS 696630-67-8)
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- Tau Peptide (304-318) trifluoroacetate salt (CAS 330456-49-0)
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