Bumetanide Impurity 21 CAS CATO-C4X-198621
| CAS No. | CATO-C4X-198621 |
| Molecular Formula | C19H15NO6S |
| Molecular Weight | 385.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Bumetanide Impurity 21 (CAS CATO-C4X-198621, C19H15NO6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Bumetanide Impurity 21 (C19H15NO6S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Bumetanide Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H15NO6S |
| Molecular Weight | 385.39 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Bumetanide Standards
- Bumetanide Impurity 8 (CAS CATO-C4X-198681)
- Bumetanide Impurity 82 (CAS CATO-C4X-198682)
- Bumetanide Impurity 100 (CAS CATO-C4X-1986100)
- Bumetanide Impurity 101 (CAS CATO-C4X-1986101)
- Bumetanide Impurity 11 (CAS CATO-C4X-198611)
- Bumetanide Impurity 121 (CAS CATO-C4X-1986121)
- Bumetanide Impurity 61 (CAS 94610-14-7)
- Bumetanide Impurity 87 (CAS CATO-C4X-198687)
Recommended Standards
- Trelagliptin Impurity 73 (CAS CATO-C4X-104673)
- Ethyl 4-(2,3-difluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-4-hydroxypiperidine-1-carboxylate (CAS 1161838-18-1)
- N-(4-{[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-1-yl]sulfonyl}phenyl)acetamide (CAS 955976-38-2)
- 1-(4-((3-(3-(Pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)sulfonyl)phenyl)ethan-1-one (CAS 1324680-00-3)
- Pyridoxine /Vitamin B6 Impurity 64 (CAS 2775363-46-5)
- Terazosin EP Impurity G (CAS 105356-89-6)
- Difelikefalin Impurity 74 (CAS CATO-C4X-304174)
- 2,4-Dimethyl-3-(4-methoxyphenyl)propiophenone (CAS 898775-82-1)
- 3-[(3-Ethyl-1-adamantyl)oxy]propan-1-ol (CAS 1266679-00-8)
- 5-Hydroxy-Clethodim Sulfoxide (CAS 111031-08-4)
- 2-(Methylthio)benzo[d]oxazole-6-acetonitrile (CAS 1806343-48-5)
- 4-Chloro-2-hydroxy-6-(trifluoromethyl)pyridine (CAS 1196154-31-0)
- 1,3,5,7-Tetrakis(4-ethynylphenyl)adamantane (CAS 144970-32-1)
- Protein Kinase C (19-36) Peptide (CAS 113731-96-7)
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