Terazosin EP Impurity G CAS 105356-89-6
| CAS No. | 105356-89-6 |
| Molecular Formula | C18H23N5O4 |
| Molecular Weight | 373.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Terazosin EP Impurity G.
As a process- or degradation-related impurity, Terazosin EP Impurity G (CAS 105356-89-6, C18H23N5O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Terazosin EP Impurity G (C18H23N5O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Terazosin EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H23N5O4 |
| Molecular Weight | 373.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 5 |
Related Terazosin Standards
- Terazosin EP Impurity H HCl (CAS 111013-28-6)
- Terazosin EP Impurity H (CAS 105356-90-9)
- Terazosin EP Impurity K (CAS 19216-56-9)
- (R)-Terazosin (CAS 109351-34-0)
- Terazosin EP Impurity B (CAS 1177261-73-2)
- Terazosin EP Impurity J (CAS 152551-75-2)
- Terazosin Impurity 23 (CAS 1260939-66-9)
- Terazosin EP Impurity F (CAS 109678-71-9)
Recommended Standards
- Cinacalcet Impurity 81 (CAS CATO-C4X-105981)
- Cinacalcet N-Oxide (CAS 1229224-94-5)
- Ceftizoxime Ring-opening decarboxylation S-oxide 2 (CAS CATO-C4X-179340)
- tert-Butyl 4-(2-amino-1-(4-(trifluoromethyl)phenyl)ethyl)piperazine-1-carboxylate (CAS 444892-59-5)
- Urapidil Impurity 11 (CAS 91453-03-1)
- Nintedanib Impurity 104 (CAS CATO-C4X-1814104)
- Methotrexate impurity N3 (CAS 65148-64-3)
- 2-((6-Acetamidopyridin-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (CAS 343373-14-8)
- N-(2-(phenylthio)ethyl)-2-(p-tolyl)acetamide (CAS 477886-12-7)
- 2-BROMO-5-METHYL-PHENYLAMINE 2-BROMO-5-METHYLANILINE 2-BROMO-5-METHYLBENZENAMINE 3-AMINO-4-BROMOTOLUENE 53078-85-6 BC002762 BENZENAMINE, 2-BROMO-5-METHYL- (CAS 53078-85-6)
- N-(2-(Benzo[d]oxazol-2-yl)ethyl)-[1,1'-biphenyl]-4-sulfonamide (CAS 926283-46-7)
- Taletrectinib Impurity7 (CAS 1012344-76-1)
- (5-(3-Methylthiophen-2-yl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone (CAS 710987-10-3)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
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