Melphalan Impurity 36 CAS CATO-C4X-198836
| CAS No. | CATO-C4X-198836 |
| Molecular Formula | C25H28Cl2N2O5 |
| Molecular Weight | 507.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Melphalan Impurity 36 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 507.41 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Melphalan Impurity 36 (CAS CATO-C4X-198836) is a certified pharmaceutical impurity reference standard with the molecular formula C25H28Cl2N2O5 and a molecular weight of 507.41 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H28Cl2N2O5 |
| Molecular Weight | 507.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Melphalan Standards
- Melphalan Flufenamide (CAS 380449-51-4)
- Melphalan Impurity 24 (CAS CATO-C4X-198824)
- Melphalan Impurity 35 (CAS CATO-C4X-198835)
- Melphalan Impurity 33 (CAS CATO-C4X-198833)
- Melphalan Impurity 25 (CAS CATO-C4X-198825)
- Melphalan EP Impurity G (CAS 2238824-43-4)
- Melphalan Impurity 26 (CAS CATO-C4X-198826)
- Melphalan Impurity 27 (CAS CATO-C4X-198827)
Recommended Standards
- Carbamic acid,n-[[4-(2,4-dichlorophenyl)-6-[2-(dimethylamino)-2-oxoethyl]-6,7-dihydro-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-3-yl]methyl]-,1,1-dimethylethylester (CAS 915731-88-3)
- 1,1,1-Trifluoro-N-[(11bS)-8,9,10,11,12,13,14,15-octahydro-2,6-dimethyl-4-oxidodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl]methanesulfonamide (CAS 2757287-62-8)
- 7-[4-(Morpholine-4-sulfonyl)phenoxy]-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 338412-25-2)
- Chlorhexidine Impurity 6 (CAS 62247-48-7)
- Nemonoxacin Impurity 89 (CAS CATO-C4X-312889)
- Cefodizime Oxide Impurity 1 (CAS CATO-C4X-18068)
- Tranilast Impurity 1 (CAS 70806-55-2)
- 2-(Difluoromethyl)-3-hydroxy-6-methylpyridine-5-carbonyl chloride (CAS 1805486-31-0)
- 2-(Pyrrolidin-1-yl)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 2213446-70-7)
- Benzyl 3-(prop-2-yn-1-yl)piperidine-1-carboxylate (CAS 2229716-46-3)
- (1S)-1-(5-methyl-1,2-oxazol-3-yl)ethan-1-ol (CAS 119596-06-4)
- 4-Iodo-1-methyl-5-((3,3,3-trifluoropropoxy)methyl)-1H-pyrazol-3-amine (CAS 1354704-27-0)
- 7-Hydroxy-3,3-dimethylindolin-2-one (CAS 87234-74-0)
- Semaglutide impurity 235 (CAS CATO-C4X-2226235)
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