Melphalan Flufenamide CAS 380449-51-4
| CAS No. | 380449-51-4 |
| Molecular Formula | C24H30Cl2FN3O3 |
| Molecular Weight | 498.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Melphalan Flufenamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Melphalan Flufenamide (CAS 380449-51-4), molecular formula C24H30Cl2FN3O3 and molecular weight 498.42 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Melphalan Flufenamide (C24H30Cl2FN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 498.42 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Melphalan Flufenamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H30Cl2FN3O3 |
| Molecular Weight | 498.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Melphalan Standards
- Melphalan Impurity 36 (CAS CATO-C4X-198836)
- Melphalan Impurity 24 (CAS CATO-C4X-198824)
- Melphalan Impurity 35 (CAS CATO-C4X-198835)
- Melphalan Impurity 33 (CAS CATO-C4X-198833)
- Melphalan Impurity 25 (CAS CATO-C4X-198825)
- Melphalan Impurity 26 (CAS CATO-C4X-198826)
- Melphalan Impurity 27 (CAS CATO-C4X-198827)
- Melphalan Impurity 20 (CAS 97338-02-8)
Recommended Standards
- 1-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[5-(3-nitrophenyl)-1H-pyrazol-3-yl]piperidine (CAS 1025724-72-4)
- (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4,5,6,7-tetrafluoro-1H-indol-3-yl)propanoic acid (CAS 281655-59-2)
- Bedaquiline Impurity 54 (CAS CATO-C4X-116754)
- N-(2,3-dichlorophenyl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332907-22-9)
- 3,6-Di-tert-Butyl-9-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-9h-carbazole (CAS 764710-77-2)
- 5-(2,3,4-Trimethoxyphenyl)pentanoic acid (CAS 859785-14-1)
- (1S,4S,5R)-3,3-dibenzyl-6,8-dioxabicyclo[3.2.1]Octan-4-ol (CAS 2229856-26-0)
- 1-(2-Chloro-6-fluorobenzyl)-4-(4-fluorobenzoyl)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 317833-37-7)
- Ethyl 2,2-difluoro-2-(4-hydroxypiperidin-4-yl)acetate (CAS 1250838-55-1)
- 3,4-Difluoro-5-nitroacetophenone (CAS 1806388-56-6)
- 5-Methoxy-N-(2-morpholin-4-ylethyl)-1,3-benzothiazol-2-amine (CAS 1105189-14-7)
- Sodium 3-oxo-3-(pyrazin-2-yl)prop-1-en-1-olate (CAS 1344802-64-7)
- Nitroso Perindopril EP impurity V (CAS CATO-C4X-125259)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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