Crisaborole impurity 111 CAS CATO-C4X-2021111
| CAS No. | CATO-C4X-2021111 |
| Molecular Formula | C14H8BrNO2 |
| Molecular Weight | 302.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Crisaborole impurity 111 (CAS CATO-C4X-2021111, C14H8BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Crisaborole impurity 111 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 302.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crisaborole impurity 111 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H8BrNO2 |
| Molecular Weight | 302.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole impurity 104 (CAS CATO-C4X-2021104)
- Crisaborole Impurity 134 (CAS CATO-C4X-2021134)
- Crisaborole impurity 150 (CAS CATO-C4X-2021150)
- Crisaborole impurity 151 (CAS CATO-C4X-2021151)
- Crisaborole Impurity 102 (CAS CATO-C4X-2021102)
- Crisaborole impurity 112 (CAS CATO-C4X-2021112)
- Crisaborole Impurity 135 (CAS CATO-C4X-2021135)
- Crisaborole impurity 153 (CAS CATO-C4X-2021153)
Recommended Standards
- Bromfenac Impurity 71 (CAS CATO-C4X-200271)
- 55644-08-1 Dimethylbis(alpha-bromoisopropyl)silane (CAS 55644-08-1)
- tert-Butyl 5-bromo-2-nitrobenzoate (CAS 2854382-74-2)
- Cenobamate Impurity 30 (CAS 913088-92-3)
- Levosimendan impurity 74 (CAS CATO-C4X-130874)
- Relebactam Impurity 118 (CAS 2650050-02-3)
- Oxybutynin Impurity 6 (CAS 76142-48-8)
- 2-Propylpyridin-4-carboxamide (CAS 80944-48-5)
- (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid sulfuric acid salt (CAS 21881-27-6)
- 2-Bromo-1-chloro-4-fluoro-3-nitrobenzene (CAS 1807121-30-7)
- 7-chloro-3-methyl-thieno[2,3-c]pyridine-4-carboxylic acid (CAS 2306262-10-0)
- 1-(2-(O-tolyloxy)ethyl)-1H-indole-3-carbaldehyde (CAS 299935-67-4)
- 6-Fluoro-2H-pyrazolo[3,4-b]pyridine-3-carbonitrile (CAS 155601-83-5)
- Semaglutide impurity 63 (CAS CATO-C4X-222663)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com