Crisaborole impurity 151 CAS CATO-C4X-2021151
| CAS No. | CATO-C4X-2021151 |
| Molecular Formula | C14H8BrNO2 |
| Molecular Weight | 302.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 302.12 g/mol gives Crisaborole impurity 151 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Crisaborole impurity 151 (CAS CATO-C4X-2021151) is a certified pharmaceutical impurity reference standard with the molecular formula C14H8BrNO2 and a molecular weight of 302.12 g/mol.
Crisaborole impurity 151 (C14H8BrNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crisaborole impurity 151 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H8BrNO2 |
| Molecular Weight | 302.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole impurity 104 (CAS CATO-C4X-2021104)
- Crisaborole impurity 111 (CAS CATO-C4X-2021111)
- Crisaborole Impurity 134 (CAS CATO-C4X-2021134)
- Crisaborole impurity 150 (CAS CATO-C4X-2021150)
- Crisaborole Impurity 102 (CAS CATO-C4X-2021102)
- Crisaborole impurity 112 (CAS CATO-C4X-2021112)
- Crisaborole Impurity 135 (CAS CATO-C4X-2021135)
- Crisaborole impurity 153 (CAS CATO-C4X-2021153)
Recommended Standards
- Cenobamate Impurity 30 (CAS 913088-92-3)
- Cenobamate Impurity 41 (CAS CATO-C4X-241641)
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- Bromopride Impurity 1 (CAS 4093-34-9)
- Tafluprost Impurity 26 (CAS 2982661-03-8)
- Avanafil Impurity 137 (CAS CATO-C4X-1118137)
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- 2-Amino-2-(quinolin-2-yl)acetic acid (CAS 500755-98-6)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com