Crisaborole Impurity 135 CAS CATO-C4X-2021135
| CAS No. | CATO-C4X-2021135 |
| Molecular Formula | C14H10BrNO2 |
| Molecular Weight | 304.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Crisaborole Impurity 135 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Crisaborole Impurity 135 (CAS CATO-C4X-2021135, C14H10BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Crisaborole Impurity 135 (C14H10BrNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H10BrNO2 |
| Molecular Weight | 304.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 102 (CAS CATO-C4X-2021102)
- Crisaborole impurity 112 (CAS CATO-C4X-2021112)
- Crisaborole impurity 153 (CAS CATO-C4X-2021153)
- Crisaborole impurity 154 (CAS CATO-C4X-2021154)
- Crisaborole Impurity 33 (CAS 906673-45-8)
- Crisaborole Impurity 23 (CAS CATO-C4X-202123)
- Crisaborole Impurity 24 (CAS CATO-C4X-202124)
- Crisaborole Impurity 25 (CAS CATO-C4X-202125)
Recommended Standards
- N-(2-Bromodibenzo[b,d]furan-3-yl)acetamide (CAS 82191-22-8)
- Methyl 5-bromo-4,6-diethoxypicolinate (CAS 2504032-30-6)
- 6-(4-AMINOPHENYL)-3-BROMOPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE (CAS 1039364-84-5)
- Methyl 5-Bromo-1-Boc-1H-pyrrole-2-carboxylate (CAS 924708-81-6)
- Lodoxamide Impurity 6 (CAS 75235-35-7)
- Epalrestat impurity 36 (CAS CATO-C4X-223636)
- Sulfadiazine Impurity 18 (CAS 345936-70-1)
- Dinaphtho[2,3-b;2',3'-d]furan" (CAS 242-51-3)
- 2-((Furan-2-ylmethyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate (CAS 387853-55-6)
- (2-Hydroxy-3,5-dimethylphenyl)boronic acid (CAS 259209-23-9)
- 3-Methoxybenzofuran-2-carboxylic acid (CAS 104315-56-2)
- 4-Methoxy-4-(o-tolyl)piperidine (CAS 793664-56-9)
- 3-(5,6-Dichloro-1h-indol-2-yl)acrylic acid (CAS 1000934-09-7)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
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