Crisaborole Impurity 24 CAS CATO-C4X-202124
| CAS No. | CATO-C4X-202124 |
| Molecular Formula | C13H8BrNO3 |
| Molecular Weight | 306.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Crisaborole Impurity 24 (CAS CATO-C4X-202124), a pharmacopoeial impurity reference standard (molecular formula C13H8BrNO3, MW 306.11 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Crisaborole Impurity 24 (C13H8BrNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 306.11 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H8BrNO3 |
| Molecular Weight | 306.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 23 (CAS CATO-C4X-202123)
- Crisaborole Impurity 25 (CAS CATO-C4X-202125)
- Crisaborole Impurity 102 (CAS CATO-C4X-2021102)
- Crisaborole impurity 112 (CAS CATO-C4X-2021112)
- Crisaborole Impurity 135 (CAS CATO-C4X-2021135)
- Crisaborole impurity 153 (CAS CATO-C4X-2021153)
- Crisaborole impurity 154 (CAS CATO-C4X-2021154)
- Crisaborole Impurity 33 (CAS 906673-45-8)
Recommended Standards
- n-(1h-Benzo[d]imidazol-2-yl)-5-bromofuran-2-carboxamide (CAS 313231-24-2)
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- 7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol (CAS 440122-66-7)
- N-(4-Nitro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (CAS 1150271-73-0)
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- Orlistat Impurity 15 ((S,E)-Henicos-7-en-10-ol) (CAS 68711-41-1)
- Cyantraniliprole Impurity IN-RYA13 (CAS 2957882-50-5)
- 4-bromo-3-methoxy-1,2-thiazole-5-carbaldehyde (CAS 1955540-11-0)
- Methyl 2-(3-(3-methoxyphenyl)-1H-1,2,4-triazol-1-yl)acetate (CAS 1416344-09-6)
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- 1,4-Difluoro-2-(isocyano(tosyl)methyl)benzene (CAS 668981-01-9)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com