Crisaborole impurity 155 CAS CATO-C4X-2021155
| CAS No. | CATO-C4X-2021155 |
| Molecular Formula | C14H13BrO2 |
| Molecular Weight | 293.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Crisaborole impurity 155 (CAS CATO-C4X-2021155, C14H13BrO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Crisaborole impurity 155 (C14H13BrO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures Crisaborole impurity 155 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H13BrO2 |
| Molecular Weight | 293.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole lmpurity 83 (CAS CATO-C4X-202183)
- Crisaborole Impurity 141 (CAS CATO-C4X-2021141)
- Crisaborole impurity 152 (CAS CATO-C4X-2021152)
- Crisaborole impurity 125 (CAS CATO-C4X-2021125)
- Crisaborole lmpurity 94 (CAS 947162-20-1)
- Crisaborole lmpurity 96 (CAS 526218-72-4)
- Crisaborole lmpurity 77 (CAS CATO-C4X-202177)
- Crisaborole impurity 104 (CAS CATO-C4X-2021104)
Recommended Standards
- Qstatin 902688-24-8 (CAS 902688-24-8)
- N-Boc-pyrrole-2-boronic Acid Pinacol Ester (CAS 1072944-98-9)
- N-benzyl-4-bromo-N-methyl-1H-pyrrole-2-carboxamide (CAS 931050-21-4)
- 3-Oxo-3H-phenoxazin-7-yl dihydrogen phosphate (CAS 108887-08-7)
- Levomilnacipran Pthalimido Impurity (CAS 1237261-65-2)
- Vilazodone impurity 02 (CAS 163521-11-7)
- Dapagliflozin dibromide impurity (CAS 1043252-56-7)
- 1-(3-Fluorophenyl)-2-(1h-imidazol-1-yl)ethan-1-one (CAS 630403-99-5)
- 2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic Acid (CAS 314042-01-8)
- 3-Allyl-4-(benzyloxy)-5-methoxybenzohydrazide (CAS 1706451-53-7)
- Deucravacitinib Impurity 15 (CAS 2417137-50-7)
- Palbociclib Impurity 65 (CAS CATO-C4X-112565)
- 3-(4-Dimethylamino-benzylidene)-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid (CAS 380574-56-1)
- D-Trp25-Tirzepatide (CAS CATO-CPTD788909)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com