Crisaborole impurity 152 CAS CATO-C4X-2021152
| CAS No. | CATO-C4X-2021152 |
| Molecular Formula | C14H11BrO2 |
| Molecular Weight | 291.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Crisaborole impurity 152 (CAS CATO-C4X-2021152) is a certified pharmaceutical impurity reference standard with the molecular formula C14H11BrO2 and a molecular weight of 291.14 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system, Crisaborole impurity 152 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 291.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crisaborole impurity 152 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H11BrO2 |
| Molecular Weight | 291.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole lmpurity 83 (CAS CATO-C4X-202183)
- Crisaborole impurity 155 (CAS CATO-C4X-2021155)
- Crisaborole impurity 125 (CAS CATO-C4X-2021125)
- Crisaborole lmpurity 94 (CAS 947162-20-1)
- Crisaborole lmpurity 96 (CAS 526218-72-4)
- Crisaborole Impurity 141 (CAS CATO-C4X-2021141)
- Crisaborole lmpurity 77 (CAS CATO-C4X-202177)
- Crisaborole lmpurity 89 (CAS 1187187-13-8)
Recommended Standards
- Telmisartan Impurity 20 (CAS 150766-86-2)
- Ozenoxacin Impurity 66 (CAS 23612-56-8)
- 632300-46-0 4-[(2-bromobenzyl)oxy]benzaldehyde DTXSID60351909 (CAS 632300-46-0)
- Abemaciclib impurity 106 (CAS CATO-C4X-2937106)
- Chlorhexidine Impurity 6 (CAS 62247-48-7)
- Isavuconazole Impurity 213 (CAS CATO-C4X-1236213)
- Celecoxib Impurity 77 (CAS CATO-C4X-104377)
- Tedizolid Impurity 8 (CAS CATO-C4X-10548)
- Rel-(1R,3S)-3-aminotetrahydro-2H-thiopyran 1-oxide (CAS 117593-50-7)
- tert-Butyl 4-(methylsulfonyl)piperazine-1-carboxylate (CAS 164331-38-8)
- 2,6-Dimethyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carbonyl chloride (CAS 146979-79-5)
- Sulfotep (CAS 3689-24-5)
- 3-Amino-indan-5-sulfonic acid cyclopentylamide (CAS 1361116-04-2)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com