Crisaborole lmpurity 96 CAS 526218-72-4
| CAS No. | 526218-72-4 |
| Molecular Formula | C14H10BrNO |
| Molecular Weight | 288.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Crisaborole lmpurity 96 (CAS 526218-72-4), a pharmacopoeial impurity reference standard (molecular formula C14H10BrNO, MW 288.14 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Crisaborole lmpurity 96 (C14H10BrNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Crisaborole lmpurity 96 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10BrNO |
| Molecular Weight | 288.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole impurity 125 (CAS CATO-C4X-2021125)
- Crisaborole lmpurity 94 (CAS 947162-20-1)
- Crisaborole lmpurity 77 (CAS CATO-C4X-202177)
- Crisaborole impurity 152 (CAS CATO-C4X-2021152)
- Crisaborole lmpurity 83 (CAS CATO-C4X-202183)
- Crisaborole lmpurity 89 (CAS 1187187-13-8)
- Crisaborole Impurity 30 (CAS 2988644-41-1)
- Crisaborole impurity 155 (CAS CATO-C4X-2021155)
Recommended Standards
- 2-(2-(2,6-Dichlorophenyl)thiazol-5-yl)acetic acid (CAS 1010872-22-6)
- 2-[2-(2,3-dichlorophenyl)-1,3-thiazol-4-yl]acetic acid (CAS 1094293-77-2)
- 19932-27-5 2-(2,2,3,3,4,4,5,5-octafluoropentoxymethyl)oxirane 2-[2,2,3,3,4,4,5,5-octakis(fluoranyl)pentoxymethyl]oxirane A814089 (CAS 19932-27-5)
- 2-(2,3-Dichlorophenyl)-4-methyl-1,3-thiazole-5-carboxylic acid (CAS 1094457-01-8)
- Varenicline Impurity N22 (CAS 2759288-58-7)
- Pazopanib Impurity 31 (CAS CATO-C4X-172531)
- Alogliptin Impurity 44-d3 (CAS 1794937-18-0)
- 4-Bromo-2-chloro-1-((4-fluorobenzyl)oxy)benzene (CAS 2092911-81-2)
- Diethoxydiphenylsilane (CAS 2553-19-7)
- Ethyl 5-oxo-1-(p-tolyl)-1,2,3,5-tetrahydroimidazo[1,2-a]pyrimidine-6-carboxylate (CAS 147821-52-1)
- 1-[1,1-Dimethylethoxy) carbonyl] - 4-piperidinepropanoic Acid Methyl Ester (CAS 162504-75-8)
- N-(5-Amino-2-methylphenyl)-4-fluorobenzamide (CAS 926204-52-6)
- {3-[(1h-imidazol-1-yl)methyl]phenyl}methanol (CAS 151055-79-7)
- Semaglutide impurity 36 (CAS CATO-C4X-222636)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com