Crisaborole Impurity 67 CAS CATO-C4X-202167
| CAS No. | CATO-C4X-202167 |
| Molecular Formula | C18H21BO4 |
| Molecular Weight | 312.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Crisaborole Impurity 67 is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Crisaborole Impurity 67 (CAS CATO-C4X-202167) is a certified pharmaceutical impurity reference standard with the molecular formula C18H21BO4 and a molecular weight of 312.17 g/mol.
The molecular framework of Crisaborole Impurity 67 (C18H21BO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crisaborole Impurity 67 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H21BO4 |
| Molecular Weight | 312.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Crisaborole Standards
- Crisaborole impurity 120 (CAS CATO-C4X-2021120)
- Crisaborole Impurity 31 (CAS CATO-C4X-202131)
- Crisaborole Impurity 60 (CAS CATO-C4X-202160)
- Crisaborole Impurity 51 (CAS 2925547-76-6)
- Crisaborole impurity 132 (CAS CATO-C4X-2021132)
- Crisaborole Impurity 69 (CAS CATO-C4X-202169)
- Crisaborole lmpurity 73 (CAS 2473730-47-9)
- Crisaborole lmpurity 95 (CAS CATO-C4X-202195)
Recommended Standards
- N-(2-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-yl)hydroxylamine (CAS 955961-74-7)
- Methyl 3-amino-4-bromo-5-phenylthiophene-2-carboxylate (CAS 1000409-69-7)
- Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate (CAS 409369-93-3)
- 4-Bromo-N-(dicyclopropylmethyl)-2-fluorobenzamide (CAS 1015676-01-3)
- Atrasentan Impurity 40 (CAS 178738-92-6)
- Dopamine Impurity 89 (and Enantiomer) (CAS 482579-01-1)
- Lemborexant Impurity 66 (CAS 1450905-00-6)
- 1-(Morpholinomethyl)indoline-2,3-dione (CAS 6532-16-7)
- (E)-2-Nitro-5-(3,4,5-trimethoxystyryl)furan (CAS 832127-79-4)
- 8-Bromo-2-(trifluoromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 2648773-62-8)
- 1-(7-(Bromomethyl)benzo[d]oxazol-2-yl)ethanone (CAS 1806572-94-0)
- 3-Mesityl-2,2-dimethylpropan-1-amine (CAS 1267088-26-5)
- 4,4-Dibromo-3-phenylisoxazol-5(4H)-one (CAS 61656-38-0)
- Cholecystokinin Octapeptide (1-4) (desulfated) (CAS 80790-40-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com