Osimertinib Impurity 46 CAS CATO-C4X-204546
| CAS No. | CATO-C4X-204546 |
| Molecular Formula | C32H44N8O2 |
| Molecular Weight | 572.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Osimertinib Impurity 46 (C32H44N8O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Osimertinib Impurity 46 (CAS CATO-C4X-204546) is a certified pharmaceutical impurity reference standard with the molecular formula C32H44N8O2 and a molecular weight of 572.74 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Osimertinib Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H44N8O2 |
| Molecular Weight | 572.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
Related Osimertinib Standards
- Osimertinib Impurity 108 (CAS CATO-C4X-2045108)
- Osimertinib Impurity 68 (CAS CATO-C4X-204568)
- Osimertinib Impurity 57 (CAS CATO-C4X-204557)
- Osimertinib impurity 58 (CAS CATO-C4X-204558)
- Osimertinib Impurity 117 (CAS CATO-C4X-2045117)
- Osimertinib Impurity 31 (CAS CATO-C4X-204531)
- Osimertinib impurity 59 (CAS CATO-C4X-204559)
- Osimertinib Impurity 97 (CAS CATO-C4X-204597)
Recommended Standards
- Indacaterol Impurity 61 (CAS CATO-C4X-150061)
- Alectinib Impurity 47 (CAS CATO-C4X-283647)
- Indacaterol Impurity 48 (CAS 1384189-12-1)
- Alectinib Impurity 64 (CAS CATO-C4X-283664)
- CAS CATO-C3D-262680 (CAS CATO-C3D-262680)
- Alogliptin Impurity 93 (CAS CATO-C4X-109993)
- Haloperidol impurity 24 (CAS 3110-52-9)
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- (2-(Difluoromethoxy)pyrimidin-4-yl)methanamine (CAS 1312096-01-7)
- Cholecystokinin Octapeptide (desulfated) (CAS 25679-24-7)
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