Osimertinib Impurity 45 CAS CATO-C4X-204545
| CAS No. | CATO-C4X-204545 |
| Molecular Formula | C23H21N5O3 |
| Molecular Weight | 415.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Osimertinib Impurity 45 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Osimertinib Impurity 45 (CAS CATO-C4X-204545) is a certified pharmaceutical impurity reference standard with the molecular formula C23H21N5O3 and a molecular weight of 415.44 g/mol.
The molecular framework of Osimertinib Impurity 45 (C23H21N5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Osimertinib Impurity 45 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H21N5O3 |
| Molecular Weight | 415.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Osimertinib Standards
- Osimertinib Impurity 12 (CAS 2213409-62-0)
- Osimertinib Impurity N3 (CAS 1820891-36-8)
- Osimertinib Impurity 62 (CAS CATO-C4X-204562)
- Osimertinib Impurity 3 (AZD9291 Impurity 3) (CAS CATO-C4X-20453)
- Osimertinib Impurity 66 (CAS CATO-C4X-204566)
- Osimertinib Impurity 16 (CAS 2044704-62-1)
- Osimertinib Impurity 54 (CAS 27065-95-8)
- Osimertinib Impurity 114 (CAS CATO-C4X-2045114)
Recommended Standards
- N-Nitroso Olodaterol (CAS CATO-C4X-19432)
- Pemafibrate Impurity 70 (CAS CATO-C4X-290370)
- Ceftizoxime Impurity 86 (CAS CATO-C4X-179386)
- H-Pro-His-Tyr-OH (CAS 81075-04-9)
- Dequalinium Impurity 14 (CAS CATO-C4X-193614)
- Pitavastatin Impurity 136 (CAS 1611991-87-7)
- Ampicillin Trihydrate EP Impurity M (CAS CATO-C4X-144344)
- Ethyl 3-(tert-Butyl)-1,2,4-oxadiazole-5-carboxylate (CAS 163719-73-1)
- Atrasentan Impurity 208 (CAS CATO-C4X-3347208)
- 6-(5-Chloro-2-methoxyphenyl)pyrimidin-4-amine (CAS 1369020-39-2)
- (±)-MDA hydrochloride (CAS 6292-91-7)
- n-(2,3-Dihydro-1h-inden-5-yl)-2-ethoxyacetamide (CAS 892720-60-4)
- 1-(4-Amino-3-fluorophenyl)pyrrolidin-2-one (CAS 927870-59-5)
- Calcineurin Autoinhibitory Peptide (CAS 148067-21-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com