Ruxolitinib Impurity 131 CAS CATO-C4X-2058131
| CAS No. | CATO-C4X-2058131 |
| Molecular Formula | C13H8Cl2N6 |
| Molecular Weight | 319.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Ruxolitinib Impurity 131 (CAS CATO-C4X-2058131, C13H8Cl2N6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ruxolitinib Impurity 131 (C13H8Cl2N6) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 319.15 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H8Cl2N6 |
| Molecular Weight | 319.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 207 (CAS 1809535-64-5)
- Ruxolitinib Impurity N7 (Mixture of Diastereomers) (CAS 1092973-95-9)
- Ruxolitinib Impurity 116 (CAS CATO-C4X-2058116)
- Ruxolitinib Impurity 117 (CAS CATO-C4X-2058117)
- Ruxolitinib Impurity 120 (CAS 1092973-94-8)
- Ruxolitinib Impurity 32 (CAS 1315607-85-2)
- Ruxolitinib Impurity 33 (CAS 1809535-63-4)
- Ruxolitinib Impurity 35 (CAS CATO-C4X-205835)
Recommended Standards
- 890099-19-1 2-(3-Bromobenzoyl)phenyl acetate DTXSID70641565 (CAS 890099-19-1)
- (1-(tert-butoxycarbonyl)-5-isopropoxy-1H-indol-2-yl)boronic acid (CAS 1021342-98-2)
- Salbutamol RC 1 (CAS 5324-15-2)
- 4-Oxo-4-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amino)butanoic acid (CAS 1030269-28-3)
- Mebeverine EP Impurity H (CAS 2514745-46-9)
- Ranitidine Hydrochloride EP Impurity B (CAS 91224-69-0)
- Sitagliptin Impurity 79 (CAS 81228-09-3)
- 6-Imino-1,3-dimethyl-6,9-dihydro-1H-purin-2(3H)-one (CAS 671792-62-4)
- 5-(Aminomethyl)thiophene-3-carbonitrile (CAS 232280-88-5)
- Tofacitinib Impurity 49 (CAS 2459302-78-2)
- 2-[1-(methoxymethyl)cyclopropyl]acetonitrile (CAS 1188283-95-5)
- 2-Cyclopropoxy-4-iodo-N-methylaniline (CAS 1243368-52-6)
- 8-Fluoro-7-methoxy-2H-benzo[d][1,3]oxazine-2,4(1H)-dione (CAS 2137981-19-0)
- Semaglutide Impurity 184 (CAS CATO-C4X-2226184)
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