Ruxolitinib Impurity 226 CAS CATO-C4X-2058226
| CAS No. | CATO-C4X-2058226 |
| Molecular Formula | C17H18N6O3 |
| Molecular Weight | 354.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Ruxolitinib Impurity 226 (CAS CATO-C4X-2058226) is a certified pharmaceutical impurity reference standard with the molecular formula C17H18N6O3 and a molecular weight of 354.36 g/mol.
Based on its molecular formula C17H18N6O3, Ruxolitinib Impurity 226 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 354.36 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Ruxolitinib Impurity 226 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H18N6O3 |
| Molecular Weight | 354.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 221 (CAS CATO-C4X-2058221)
- Ruxolitinib Impurity 121 (CAS CATO-C4X-2058121)
- Ruxolitinib Impurity 65 (CAS CATO-C4X-205865)
- Ruxolitinib Impurity 115 (CAS CATO-C4X-2058115)
- Ruxolitinib impurity 52 (CAS CATO-C4X-205852)
- Ruxolitinib Impurity 53 (CAS CATO-C4X-205853)
- Ruxolitinib Impurity 127 (CAS CATO-C4X-2058127)
- Ruxolitinib Impurity 119 (CAS CATO-C4X-2058119)
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