Ruxolitinib Impurity 228 CAS CATO-C4X-2058228
| CAS No. | CATO-C4X-2058228 |
| Molecular Formula | C12H19NO3 |
| Molecular Weight | 225.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ruxolitinib Impurity 228.
As a process- or degradation-related impurity, Ruxolitinib Impurity 228 (CAS CATO-C4X-2058228, C12H19NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Ruxolitinib Impurity 228 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 225.28 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ruxolitinib Impurity 228 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H19NO3 |
| Molecular Weight | 225.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 47 (CAS CATO-C4X-205847)
- Ruxolitinib impurity 49 (CAS CATO-C4X-205849)
- Ruxolitinib Impurity 62 (CAS CATO-C4X-205862)
- Ruxolitinib Impurity 38 (CAS 1974336-79-2)
- Ruxolitinib Impurity 171 (CAS 2201066-09-1)
- Ruxolitinib Impurity 17 (CAS CATO-C4X-205817)
- Ruxolitinib Impurity 102 (CAS CATO-C4X-2058102)
- Ruxolitinib Impurity 106 (CAS CATO-C4X-2058106)
Recommended Standards
- Brivaracetam Impurity 41 (CAS CATO-C4X-200741)
- Perospirone Impurity 36 (CAS CATO-C4X-245836)
- Bisoprolol Impurity 120 (CAS 62340-37-8)
- Isoprenaline impurity 39 (CAS CATO-C4X-277539)
- Rivaroxaban Impurity 99 (CAS CATO-C4X-109099)
- Eribulin Impurity 7 (CAS 1534341-95-1)
- Tetracaine Impurity 36 (CAS CATO-C4X-192336)
- Tert-butyl (2-(fluoromethyl)cyclobutyl)carbamate (CAS 1421602-66-5)
- Ethyl 4-cyano-5-(2-((3-cyano-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2-yl)thio)acetamido)-3-methylthiophene-2-carboxylate (CAS 488108-33-4)
- (R)-2-Amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide hydrochloride (CAS 159633-92-8)
- 2-PRopylpyrrolidine oxalate (CAS 1177309-27-1)
- 3-(Nonafluoro-tert-butyl)propan-1-ol (CAS 14115-49-2)
- 3,3'-Dinitro-5,5'-bis(trifluoromethyl)biphenyl (CAS 194344-28-0)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com