Dacomitinib Impurity 2 CAS CATO-C4X-20862
| CAS No. | CATO-C4X-20862 |
| Molecular Formula | C20H19ClFN5O2 |
| Molecular Weight | 415.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dacomitinib Impurity 2 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dacomitinib Impurity 2 (CAS CATO-C4X-20862) is a certified pharmaceutical impurity reference standard with the molecular formula C20H19ClFN5O2 and a molecular weight of 415.85 g/mol.
Dacomitinib Impurity 2 (C20H19ClFN5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dacomitinib Impurity 2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H19ClFN5O2 |
| Molecular Weight | 415.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib Impurity N4 (CAS 2190490-31-2)
- Dacomitinib Impurity 24 (CAS CATO-C4X-208624)
- Dacomitinib Impurity 11 (CAS CATO-C4X-208611)
- Dacomitinib Impurity 34 (CAS CATO-C4X-208634)
- Dacomitinib Impurity 12 (CAS CATO-C4X-208612)
- Dacomitinib Impurity 33 (CAS CATO-C4X-208633)
- Dacomitinib Impurity 35 (CAS CATO-C4X-208635)
- Dacomitinib Impurity 8 (CAS CATO-C4X-20868)
Recommended Standards
- 4-((Benzo[d][1,3]dioxol-5-ylmethylene)amino)phenyl 4-chlorobenzenesulfonate (CAS 329778-29-2)
- Thiourea, N-(4-chlorophenyl)-N'-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- (CAS 1013566-44-3)
- 2-(2-Chloro-5-(phenylsulfonyl)benzamido)benzoic acid (CAS 724440-27-1)
- 2-[(2-Chlorophenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]quinoline (CAS 339103-24-1)
- Letermovir Impurity 29 (CAS CATO-C4X-291529)
- Roxadustat Impurity 117 (CAS CATO-C4X-2213117)
- Prostaglandin Impurity 23 (CAS CATO-C4X-199623)
- (S)-N-Boc-2-(7'-octenyl)glycine (CAS 115181-72-1)
- (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)undecanoic acid (CAS 1821771-29-2)
- (R)-3-(azetidin-2-yl)propanoic acid (CAS 477585-77-6)
- (3-(Bis(4-methoxybenzyl)amino)-2-fluoro-5-methylphenyl)boronic acid (CAS 2411792-25-9)
- 4-(5-(3,4-Dihydro-2H-pyrrol-5-yl)-3-methylpyridin-2-yl)morpholine (CAS 1352540-29-4)
- 1-Bromo-2-ethynyl-4-(trifluoromethoxy)benzene (CAS 2379918-32-6)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com