Dacomitinib Impurity 8 CAS CATO-C4X-20868
| CAS No. | CATO-C4X-20868 |
| Molecular Formula | C23H23ClFN5O2 |
| Molecular Weight | 455.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dacomitinib Impurity 8 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dacomitinib Impurity 8 (CAS CATO-C4X-20868) is a certified pharmaceutical impurity reference standard with the molecular formula C23H23ClFN5O2 and a molecular weight of 455.91 g/mol.
The molecular framework of Dacomitinib Impurity 8 (C23H23ClFN5O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dacomitinib Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H23ClFN5O2 |
| Molecular Weight | 455.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib Impurity 10 (CAS CATO-C4X-208610)
- Dacomitinib Impurity 35 (CAS CATO-C4X-208635)
- Dacomitinib (CAS 1110813-31-4)
- Dacomitinib Impurity 28 (CAS CATO-C4X-208628)
- Dacomitinib Impurity 32 (CAS CATO-C4X-208632)
- Dacomitinib Impurity 38 (CAS CATO-C4X-208638)
- Dacomitinib Impurity 7 (CAS CATO-C4X-20867)
- Dacomitinib Impurity 9 (CAS CATO-C4X-20869)
Recommended Standards
- Cloxacillin Impurity 20 (CAS CATO-C4X-159720)
- (R)-2-Cl-Phox-Bn (CAS 2634687-74-2)
- 2-(3-(4-Chlorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl 2-(methylthio)nicotinate (CAS 473671-25-9)
- (S)-2-Cl-Phox-Bn (CAS 2634687-64-0)
- Cyproterone Acetate EP Impurity D (CAS CATO-C4X-16012)
- Alectinib Impurity 48 (CAS CATO-C4X-283648)
- Lercanidipine Impurity 56 (CAS CATO-C4X-136456)
- tert-Butyl 4-(2-chlorobenzylamino)piperidine-1- (CAS 359877-83-1)
- N-Methoxy-N-methylnaphthalene-1-carboxamide (CAS 226931-26-6)
- Foritinib Impurity 9 (CAS CATO-C4X-33109)
- N-(Cyclopropylmethyl)-4-methylpyridin-2-amine (CAS 1250110-40-7)
- 3-Ethoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-2-methyl-3-oxopropanoic acid (CAS 1225228-89-6)
- 4-(Hydrazinylmethyl)benzonitrile (CAS 51421-23-9)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
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