Dacomitinib Impurity 20 CAS CATO-C4X-208620
| CAS No. | CATO-C4X-208620 |
| Molecular Formula | C26H32ClFN6O2 |
| Molecular Weight | 515.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 515.02 g/mol gives Dacomitinib Impurity 20 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Dacomitinib Impurity 20 (CAS CATO-C4X-208620, C26H32ClFN6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dacomitinib Impurity 20 (C26H32ClFN6O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H32ClFN6O2 |
| Molecular Weight | 515.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Dacomitinib Standards
- Dacomitinib Impurity 21 (CAS CATO-C4X-208621)
- Dacomitinib Impurity 54 (CAS CATO-C4X-208654)
- Dacomitinib Impurity 42 (CAS CATO-C4X-208642)
- Dacomitinib Impurity 48 (CAS CATO-C4X-208648)
- Dacomitinib Impurity 37 (CAS CATO-C4X-208637)
- Dacomitinib Impurity 1 (CAS CATO-C4X-20861)
- Dacomitinib Impurity 51 (CAS CATO-C4X-208651)
- Dacomitinib Impurity 6 (CAS CATO-C4X-20866)
Recommended Standards
- (Z)-[2-(Benzenesulfonyl)-1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethylidene][(4-fluorophenyl)methoxy]amine (CAS 672950-32-2)
- 4-Bromo-3,3,4,4-tetrafluorobutyl (3,3,4,4,5,5,6,6,6-nonafluorohexyl) carbonate (CAS 1980035-10-6)
- HM 50316 (CAS 1310361-52-4)
- MK-571 (CAS 115104-28-4)
- Perindopril EP Impurity O Tert-Butylamine Salt (CAS CATO-C4X-125273)
- Donepezil Impurity 53 (CAS 149874-81-7)
- Cefcapene Impurity 37 (CAS CATO-C4X-182437)
- 2-{[5-(4-methoxyphenyl)-4-(4-methylphenyl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide (CAS 893726-56-2)
- 4-Bromo-5-(methoxymethyl)-3-methylisoxazole (CAS 2167449-36-5)
- 1-({4-[(2H-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}methyl)-1H-1,2,3-benzotriazole (CAS 305859-45-4)
- Bis(4-(dimethylamino)-3-nitrophenyl)methanone (CAS 136661-37-5)
- tert-Butyl 3-((4-aminophenyl)thio)-piperidine-1-carboxylate (CAS 1196963-49-1)
- 10,10'-(5-(6-([1,1'-Biphenyl]-4-yl)-2-phenylpyrimidin-4-yl)-1,3-phenylene)bis(9,9-dimethyl-9,10-dihydroacridine) (CAS 1836192-40-5)
- Renin Inhibitor Peptide (CAS 50410-01-0)
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