Gadobutrol Impurity 1 CAS CATO-C4X-21201
| CAS No. | CATO-C4X-21201 |
| Molecular Formula | C20H38N4O10 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Gadobutrol Impurity 1.
CATO supplies Gadobutrol Impurity 1 (CAS CATO-C4X-21201), a pharmacopoeial impurity reference standard (molecular formula C20H38N4O10GdCl, MW 687.24 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Gadobutrol Impurity 1 is typically white to pale yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 687.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Gadobutrol Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H38N4O10 Gd Cl |
| Molecular Weight | 687.24 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Gadobutrol Standards
- Gadobutrol Impurity 112 (CAS 1003-83-4)
- Gadobutrol Impurity 12 4HCl (CAS 10045-25-7)
- Gadobutrol Impurity 79 (CAS 105855-71-8)
- Gadobutrol Impurity 115 (CAS 112-24-3)
- Gadobutrol EP Impurity C (Gadoteridol USP Related Compound B) (CAS 112188-16-6)
- Gadobutrol Impurity N5 (CAS 112193-75-6)
- Gadobutrol Impurity 104 4HCl (CAS 112193-75-6（free base）)
- Gadobutrol Impurity 37 (Cyclen Disulfate) (CAS 112193-77-8)
Recommended Standards
- Mitapivat Impurity 3 (CAS CATO-C4X-34533)
- Finerenone Impurity 104 (CAS CATO-C4X-2880104)
- Dexmedetomidine Impurity 26 (CAS 603-79-2)
- (2S,3S,4R,5S,6S)-6-methyltetrahydro-2H-pyran-2,3,4,5-tetraol (CAS 13224-93-6)
- 2,4-Dimethylhexan-2-ol (CAS 42328-76-7)
- n-(4-Fluorobenzyl)pyridin-3-amine (CAS 939755-76-7)
- Tert-butyl 3-amino-4-phenylpiperidine-1-carboxylate (CAS 221141-81-7)
- 4-(4-(Trifluoromethyl)phenyl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 473706-07-9)
- rac-(3R,4R)-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride (CAS 1909288-72-7)
- Peptide YY (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 81858-94-8)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com